Absolutely! In fact, throttle controllers are a great compliment to many aftermarket performance modifications.
Performance mods such as ECU Tune, Dyno Tune, ECU Remap, Power Chip or ECU Reflash focus on many parameters outside your throttle response. Parameters like fuel injection, ignition timing, boost pressure, etc. And, while some tuners also include pedal mapping in their services, it is also often non-adjustable.
The true benefit of throttle controllers lies in is its adjustability. With multiple driving modes and levels of adjustability to choose from, you can now tune your throttle response to suit any driving style or conditions.
This adjustability lets you better control the influence & effectiveness of your other performance modifications.
A perfect example of this is if your Tune/Chip/Remap may be too aggressive, like driving off-road or in wet conditions. With a throttle controller, you can subdue your throttle response and have far more control over the power to your wheels.
Alternatively, if you have the power but suffer from lag or means to access your optimal power range, the controller can enhance your throttle response!